Phenotypic diversity of Tropheryma whipplei clinical isolates

Tropheryma whipplei is a bacterial pathogen responsible for wide range of infections in humans, covering asymptomatic carriage, acute infections, chronic isolated and classic Whipple's disease. Although the bacterium commonly found environment, it very rarely causes Genetic comparison clinical isolates has revealed that main variations were region encoding T. surface glycoproteins called WiSP. However, no association been made between genetic diversity manifestations infection. In this study we evaluated phenotypic 26 from different origins taken patient with infection outcomes. MRC5 macrophages cells infected, uptake, survival pro-and anti-inflammatory potential was assessed. No significant difference phagocytosis isolates; however, replication increased bacteria expressing high molecular weight addition, expression genes coding IL-1β TGF-β significantly higher when stimulated compared to localized while differences observed macrophages. Overall, our that, as previously at level, associated WiSP, which may result subtle host responses. Other factors or predisposition explain infections.